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Proper technique, including site rotation and sterile preparation, is important for safety and comfort

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Electroporation or microneedling for deeper, more intensive penetration on either face or scalp

Active targeting builds on this baseline by directing carriers toward functional nodes, for example receptors on tumor cells or on key TME cell types such as tumor endothelial cells, cancer-associated fibroblasts and defined immune cell subsets [53, 57, 58]

The similar trend was observed for vitamin D metabolism genes (Fig

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