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It is primarily available for research purposes, and its use in humans carries regulatory and safety considerations

Cell 176 , 11431157.e1113 (2019)

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Inflammation was also driven by D3, as Drd3 deficiency improved the immunosuppressive capacity of T regs , and D3 signaling inhibited the migration of these cells into the lamina propria region of the gut (Ugalde et al., 2021)

For researchers investigating chronic low-grade inflammation (often called inflammaging), it offers a well-characterized tool compound for studying simultaneous antioxidant and anti-inflammatory responses without the systemic suppression that comes from corticosteroids or broad NSAIDs