They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)
FDA approved for type 2 diabetes, not approved for weight loss, though doctors may prescribe off-label ), weight loss is usually more modest
But GHK reverses the expression of 70% of the genes in a certain gene signature
Details can be found at: 10.3389/fonc.2025.1644727
In a mouse model of myocardial ischemia, the ferroptosis inhibitor liproxstatin-1 (Lip-1) attenuated ischemia/reperfusion (I/R)-induced GPX4 depletion and reduced mitochondrial ROS production, accompanied by decreased VDAC1 expression and preservation of mitochondrial ultrastructural integrity
The vial should be discarded immediately to avoid compromising your research