Ozempic may cause fatigue in some users, and feeling tired can sometimes affect mood, but depression is not a typical effect
(11) Y Sun, P Wang, H Zheng, R G Smith (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proceedings of the National Academy of Sciences U S A, 2004 Mar 30, Volume 101 (Issue 13), Pages 4679-84
Cold-turkey discontinuation often leads to overeating within days, reversing 3050% of your progress within months
Many people prefer injecting on Friday evenings so that peak side effects (which hit 24-48 hours after injection) occur over the weekend when they can rest
So what's the truth
Your mTOR signaling, your satellite cell response, your progressive overload adaptations, none of that is impaired by the drug