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Jastreboff et al., SURMOUNT-1 results, NEJM 2023

The time it takes for a progressive systemic effect to affect a typical person Fair to medium brown skin tone and 1-3 months Dark Brown Skin Tone, 1-6 Months 6 to 12 months Very dark complexion 12 to 24 months for a black complexion Q4: Why does it take some people a long time to achieve benefits while others do so quickly

However, a significant number of patients develop kidney dysfunction from various contributors that impact optimal renal perfusion

The early phase of GLP-1 treatment often involves significant fluid and glycogen loss alongside reduced food intake, creating a perfect storm for electrolyte depletion

There was also an association with pre-operative gastrointestinal symptoms (e.g., nausea, vomiting, abdominal pain, bloating) and the degree of residual gastric contents

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