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Immunoblot of indicated proteins in HeLa cells treated with Erastin (5 M) and co-treated with either GSH (10 mM), GSHee (10 mM), Trolox (50 uM) or Ferrostatin-1 (5 uM) for 48 hours

Both treatment arms were receiving metformin alone (84%) or in combination with a DPP 4 inhibitor (16%) as background therapy

The result is a significant reduction in hunger and calorie consumption

Individual results can vary significantly