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The scientific challenge was formidable

The data support the development of GLP-1RAs as a promising therapeutic approach for managing the multifaceted clinical manifestations of BBS

Assessments Menstrual frequencies Menstrual regularity was defined as the number of bleeds per year using self-reported menstrual intervals based on diary review

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Hypomagnesemia recurred if PPI therapy was re-introduced[226] Another recent review of 4 cases examined the clinical consequences and mechanisms of electrolyte disorders that resulted from the elderly patients taking a PPI for a period of 1 to 13 years.[227] They developed severe low magnesium levels with low calcium levels, hypoparathyroidism (low parathyroid hormone), and extremely low urinary calcium and magnesium excretion

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