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APX activity was carried out by the protocol of Nakano and Asada 60

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Residues involved in the interaction with 5-helix (H387L394) in the receptor of 2 AR (green box) and GLP-1R (purple box) are shown above and below the schematic, respectively

6e, all three GSSG-enhancing chemicals increased the levels of IKK--SSG adducts, suggesting that GSSG accumulation restrained IKK- activity by promoting IKK- S -glutathionylation, leading to subsequent NF-B suppression

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