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Moreover, in TNF--stimulated ECs, the copper-dependent ATOX1-TRAF4 interaction promotes nuclear translocation and initiates ROS-dependent inflammatory responses, solidifying this axis as a promising therapeutic target [45]

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[2], and Chinevere et al

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17 , 76 Although this study concentrated on mice, it prompts significant considerations for similar human processes, where melanocytes are found in both hair follicles and the interfollicular epidermis