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Wegovy (semaglutide 2.4 mg) is typically recommended for up to 2 years of treatment

Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma

Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function

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The authors note that additional research is needed to confirm the association, but identify this as one of the first large-scale studies examining cough risk in patients without GERD