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On the skin side, pallor, a yellowish tinge, dryness, hyperpigmented patches (particularly on the hands or face), and mouth or tongue soreness are classic signs

Part of the TMA produced by the gut microbiota is fermented to produce methane by the gut microbiota, and the rest is absorbed into the liver (41)

Szurszewski, J

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The progressive drying and keratinization of the conjunctiva, particularly on the nasal and temporal conjunctiva, results in the development of irregularly shaped spots termed Bitot (bee toe) spots after the French physician, Pierre Bitot, who first described them