At the same time, such a high flip-flop rate suggests a rapid equilibration of the distribution within the membrane
Although initially considered a waste product of aerobic glycolysis (e.g., the Warburg effect), lactate has been shown to serve as the primary carbon source for the TCA cycle in vivo, providing substrates, and thus electrons, for oxidative phosphorylation in normal tissue and tumors 2,3
[DOI] [PubMed] [Google Scholar] Nicholls S.J., Lincoff A.M., Garcia M., Bash D., Ballantyne C.M., Barter P.J., Nissen S.E
K., Thenappan, T., Bhargava, M
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