nad+glp-1 NAD+ & GLP-1 Program in Rancho Mirage Interactions between Intestinal Homeostasis and

SnapShot: Insulin/IGF1 Signaling

Three amino acid-altering GIP receptor variants (R190Q, E288G, and E354Q) are all associated with lower bone mineral density, and in postmenopausal women followed for 10 years, who were homozygous carriers of the E354Q variant, showed a higher risk of non-vertebral fractures (99, 101)

A 1.0mL syringe with 2-unit markings only measures to 2 units, which at 10mg/mL equals 0.2mg precision

doi:10.1186/s13024-023-00642-3 101

Others benefit from periodic breaks followed by reinitiation when weight begins creeping back

Example: Inject into lateral delts after shoulder training Rotate sites to avoid tissue irritation Use an insulin syringe (2931 gauge) for precision and minimal discomfort Intramuscular injection of IGFDES maximizes local growth factor concentration, significantly increasing hypertrophic response compared to systemic use. Puche et al., Molecular and Cellular Endocrinology IGFDES Side Effects and Safety Considerations While IGFDES is generally well-tolerated when used at appropriate doses, its potency and receptor affinity make it important to understand the risksespecially for beginners