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Animal models and observations in patients with opioid addiction suggested that somatic and motivational symptoms accompanying opioid withdrawal are secondary to the activation of stress-related process (mainly cortisol and catecholamines mediated)

Wand GS, Weerts EM, Kuwabara H, Wong DF, Xu X, McCaul ME

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The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing

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We used high-intensity areas in the MRA map, adjacent to the pituitary ROI, to create a bilateral internal carotid ROI (666 voxels, 5.33 mL)