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It is best understood as an emerging peptide research topic with potential relevance to gut inflammation, immune balance, and tissue-level inflammatory signaling

A substudy published in Nature Medicine enrolled 98 participants with MASLD for 48 weeks (Nature Medicine, 2024): At 12 mg, 93% of participants with fatty liver achieved normal liver fat levels

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Muscle cramps were present in 27.8% of the patients assessed in the present cohort, necessitating attention to this common complication of liver cirrhosis

"Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist"

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