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1 Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently one of the most important public health issues in the world because it is directly related to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) ( MASLD is particularly notorious for being able to accelerate the development of T2DM, a chronic metabolic disease characterized by hyperglycemia, IR, and beta cell failure ( The main pathophysiological mechanisms through which Insulin resistance (IR), hepatic lipid accumulation, and low-grade inflammation lead to MASLD and T2DM have been described ( 2 Epidemiological data With the prevention and control of many infectious diseases, Non-Communicable Diseases (NCDs) have become the leading global diseases burden ( 2.1 Global prevalence and trends of MASLD and T2DM MASLD has recently become the leading cause of chronic liver disease (CLD) and is now recognized as the most common liver disease ( Epidemiological studies indicate that MASLD is increasing rapidly worldwide, with some studies reporting a prevalence of over 40% in high-risk male populations, compared to approximately 26% in females ( It has been found that MASLD boosts the risk of developing T2DM by two to five times according to the level of hepatic fibrosis and metabolic dysfunction ( 2.2 Ethnic and racial disparities in MASLD and T2DM prevalence Racial and ethnic inequalities in the rates of MASLD and T2DM have been noted
Notably, HR-proficient tumours are often harder to treat, owing to their intrinsic resistance to DNA-damaging agents 1
Similar Muscle Loss Across Approaches, But Risk Factors Identified Study participants who were prescribed semaglutide lost more weight than those who participated in the diet and lifestyle program, but the percent of weight loss that was lean mass was similar between the two groups
