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*Correspondence: Kari Raij, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This is the population that has been invisible in the literature, and it is now the largest group using these drugs

The use of other chemical spacers was also explored, with the aim of substituting the optically active Glu with a simple, non-chiral spacer (42)

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