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In patients in hyperammonaemic crisis, laboratory testing is required to establish the cause of hyperammonaemia 24

[13] Complications [edit] Gastroparesis can lead to difficult glycemic control (which exacerbates gastric dysmotility), aspiration, bezoar formation, abnormalities in fluid and electrolyte balance, and inadequate nutrition intake resulting in weight loss

The most clinically significant of these are COL3A1 mutations causing the potentially lethal vascular form of EDS

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Moderate, occasional drinking is compatible with substantial weight loss