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Papers were excluded if they were review papers, if the study was conducted only on animals, if there was no measurement of ghrelin or GLP-1, or administration of an agonist or antagonist for the respective receptors, or when the hormonal measure or manipulation was not related to the reward response

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Finding the right person was difficult because many at the time, like Fraser, were highly sceptical about the clinical potential of RIA

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Because triple receptor specificity requires significantly more complex synthesis than single or dual agonist peptides