This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation
doi:10.1016/j.bioorg.2011.08.004
The aberrant accumulation of amyloid-beta peptide 142 (A42), hyperphosphorylated Tau into neurofibrillary tangles and cognitive decline constitute the histological and pathophysiological hallmarks of the disease, respectively (reviewed in Palop et al., 2007
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Precision medicine approaches currently experimental but likely becoming standard within coming decades
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