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By integrating current evidence on phytochemicals, heavy metal toxicity, and emerging therapeutic strategies, this work aims to support the development of multi-targeted interventions for liver diseases

Discussion In this study, we showed that cryopreserved canine primary hepatocytes in a sandwich culture are an appropriate in vitro model for canine ITZ-associated hepatotoxicity

Considerations No clinical validation: There is no evidence-based guidance on what is safe or effective in humans

This 16 to 20 week titration period exists specifically to allow the body to adapt at each dose level before increasing

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Cortisol level to exclude adrenal insufficiency: Generally, a stressed, hypoglycemic patient should have elevated cortisol levels