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MASH: A liver disease where fat builds up in the liver and causes swelling or damage

STEP 1 averaged 14.9% over 68 weeks and SURMOUNT-1's top dose averaged around 21% over 72 weeks, and both curves bend toward flat as they approach a new level

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In clinical practice, intravenous administration of andrographolide has been associated with acute tubular necrosis, with 58% cases with kidney injury occurring at a dose of 500 mg/d (Zhang et al., 2014)

These data show that the BBB is damaged in ex vivo , in vitro , and in vivo models of diabetes in association with brain microvascular endothelial cells/pericyte impairment and inflammation [79]