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Cardiometabolic disease is used as an umbrella term for all the above cases, and severity of cardiometabolic disease refers, in this manuscript, to the progression from single risk factors such as obesity to overt T2D and cardiac phenotype (ischemic heart disease and heart failure)

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Inflammation, oxidative stress, and deficits in neurotransmitters are the common features of the biochemical switch that ultimately results in the activation of the apoptotic pathways that lead to neuronal cell dysfunction and death and eventually to the neurological disorder

Snyder et al., 2011

The FDA statement also cites counterfeit medications illegally marketed in the U.S