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There is a theoretical increased risk of medullary thyroid cancers, but its not clear how likely this is to actually happen in people, says Fishman, who along with Vash stresses that the link has only ever been studied in animals

[PMC free article: PMC9659651] [PubMed: 36117266] 42

Finally, it is not uncommon to find patients with obesity and diminished mobility to have both an increase in body fat and decrease in lean (muscle) mass [58]

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This triple-receptor architecture enables researchers to study both energy intake suppression and active energy expenditure simultaneously, a mechanistic capability not available with dual or mono agonist research tools