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Anecdotal reports don't suggest any female-specific concerns

In addition, studies have reported increased expression of growth hormone receptors in tendon-derived fibroblasts following peptide exposure, a response that may amplify regenerative signaling during joint recovery processes (20)

While its topical safety record is strong, its systemic safety and efficacy for treating medical conditions have not been established through comprehensive, large-scale, independent Phase 3 human trials

PMC 4417229

This is because runoff from the soil causes selenium to collect in the water in high levels and then starts working its way up the food chain and causing problems, as shown in the following link

What to expect: Systemic benefits like improved skin quality and reduced inflammation often appear within 48 weeks