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First, although we identified and validated PPAR as a key target through bioinformatics and experimentation, we did not perform knockdown or overexpression studies in cell lines to directly confirm a causal relationship between PPAR activity and inhibition of chondrocyte ferroptosis

Xu S, Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q

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doi: 10.14219/jada.archive.1988.0065

From the 8th day, the mice in NM group were treated with Folium sennae decoction 10 g/(kgday) by gavage every afternoon, 0.4 mL/time, once a day for 7 consecutive days