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The best Dihexa dosage for cognitive enhancement typically falls within 0.5mg to 5mg administered orally in preclinical models, with neurogenesis and synaptogenesis observed at submicrogram concentrations in vitro

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van der Griend R, Biesma DH, Haas FJ, Faber JA, Duran M, Meuwissen OJ, and Banga JD (2000)

These findings are compatible with our ASK1MAX2 structures, where the CTH is unresolved/dislodged in the absence of the receptor and substrate, and present as a helix in the assembled SCF MAX2 HTL7SMAX1 complex

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Science 302 (5651), 17041709