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Acknowledgment This study was supported by Engineering and Physical Sciences Research Council (EPSRC), EP/S001301/1, Biotechnology Biological Sciences Research Council (BBSRC) BB/S016899/1, Science for Life Laboratory, Swedish National Infrastructure for Computing at SNIC through Uppsala Multidisciplinary Centre for Advanced Computational Science (UPPMAX) under projects SNIC 2020-5-222, SNIC 2019/3-226, SNIC 2020/6-153 and Kings College London computational infrastructure facility, Rosalind ( for high performance computing

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