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Each option has distinct mechanisms, benefits, and limitations

The agency notes specific risks too

It has also been shown to reduce inflammation and pain in these tissues

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If a journal publishes a correction or a retraction, Reich notes, academics whose work is called into question may sue (or threaten to do so) over the hit to their reputation, whereas whistleblowers who flag an error are unlikely to sue journals for taking no action

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)