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5.1.2 Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner

97 Moreover, it was found that caffeic acid could effectively prevent APAP-induced liver toxicity by activating the Keap1-Nrf2 antioxidative defense system

Interestingly, another large observational study linked both low and high IGF-1 levels to type 2 diabetes risk

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15 Recent policy shift