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Their conclusions similarly highlight the advantages of GLP-1RAs for weight and select metabolic/clinical phenotypes but explicitly note that the evidence chain for long-term follow-up, lean PCOS, and reproductive endpoints (ovulation, pregnancy, and live birth) remains weak

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Early formulations contained ephedra, a plant extract said to increase energy

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10.1016/j.euroneuro.2015.12.031 Summary Keywords diet, depression, gut microbiota, nutrients, brain-gut axis Citation Qiao Y, Rong L, Chen H, Guo J, Li G, Wang Q, Bi H, Wei L and Gao T (2025) Gut microbiota, nutrients, and depression