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Material and methods Study design and population We applied a new-user, active comparator cohort study design, comparing GLP-1 RA users with SGLT-2 inhibitor users and GLP-1 RA users with DPP-4 inhibitor users on the incidence of suicide or suicide attempts [19], utilizing information from registers on the entire Danish population [20]

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however, over the remaining 4 years the volume of patients remained stable

Further, a clinical study has demonstrated that the combination of GLP-1R agonist and sodiumglucose cotransporter 2 (SGLT2) inhibitors significantly reduces the risk of all cause-mortality and improves renal function, compared to GLP-1R agonist alone in type 2 diabetic patients [69]