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Because this side effect occurs consistently, it has led to interest in topiramate for obesity, but the risks associated with the drug make off-label use for weight loss inappropriate outside specialist settings

Exploratory analyses generally showed greater reductions in body weight and HbA1c over 24 months in the incretin-based therapy groups than in the conventional anti-obesity medication groups, although some comparisons varied by diabetes status and outcome measure

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Cui Y, et al

The processes regulating skin pigmentation and hair pigmentation operate independently

Based on patient reports and clinical observations: Onset (Week 2-4): Initial body aches may appear as the first gastrointestinal effects emerge