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The proinflammatory cytokine IL-1 can increase TfR1 and inhibit FPN expression, promote iron transport into the cell and reduce iron efflux, and excessive iron causes mitochondrial dysfunction through the Fenton reaction

These findings underscore a bidirectional braingutimmune axis in stroke pathology (Singh et al., 2016)

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The close votes reveal a divided committee rather than a settled scientific judgment

Redox and nitric oxide-mediated regulation of sensory neuron ion channel function