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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default
What is the distinct NAD + metabolome in each tissue
Because peptides are so specific, they tend to work best as part of a thoughtful, supervised plan rather than on their own
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