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Ethics declarations Ethics approval This study did not require ethics approval as it did not involve any human participants or animal subjects

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Multiple Endocrine Neoplasia Type 2 is a rare inherited condition that predisposes individuals to develop certain endocrine tumors, including medullary thyroid carcinoma (mentioned above)

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In TRIUMPH-4, the first Phase 3 trial to report results (December 2025), participants on the 12mg dose lost an average of 28.7% of body weight at 68 weeks, about 71 pounds