During thymic development of nTregs, the CNS2 region undergoes nearly complete DNA demethylation, which ensures the heritable stability of Foxp3 expression
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Regular injections might be needed, especially for those with specific medical conditions or deficiencies
p53 mutations affect protein dynamics, further affecting drug binding
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Through these mechanisms, vitamin D helps maintain CNS integrity and prevents neurodegenerative diseases by regulating gene expression involved in neuroinflammation [136]