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As a result, the combination of erastin and JMF4073 both at sub-micromolar concentration acts synergistically to cause lethality in these blast-crisis CML cells

Pharmacokinetic parameters such as AUC, maximum plasma concentration (Cmax), terminal elimination t1/2, volume of distribution (Va), and clearance were calculated [2]

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The reliability is tied to using the correct form for the intended experimental design