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In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within Keap1 allows Nrf2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus, where it can promote its antioxidant transcription program

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120,121 ROS are also produced via the metabolism of arachidonic acid by lipoxygenases in the presence of NADH or NADPH

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