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Melatonin reprograms the effector state of activated ILC2s To further dissect the effects we had observed, we isolated aILC2s from IL-33 challenged BALB/c mice ( Supplementary Figures 2 ) and performed bulk RNA sequencing, comparing the transcriptome of vehicle and melatonin treated cells ( Figure 5A )

They cause damage to vessels through by increasing the number of thrombins, causing NOX activation and elevated production of ROS, which leads to DNA and lipid oxidation, concurring to atherosclerosis [57], which has also been confirmed in Jagadeesha et al.s [44] research

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