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Clinicians and patients should remain vigilant for the following scenarios: Uncontrolled Hyperglycemia: In patients with type 2 diabetes, increased urination accompanied by excessive thirst (polydipsia), unexplained weight loss, or fatigue may signal inadequate glycemic control

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Abrupt withdrawal has been linked to severe complications, including Posterior Reversible Encephalopathy Syndrome (PRES), hypertensive encephalopathy, stroke, and death (Thorpe et al., 2025)