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A post-hoc analysis of the SURPASS-4 trial demonstrated that tirzepatide attenuates the decline in both eGFRcreatinine and eGFRcystatin-C and significantly reduces the urinary albumin-to-creatinine ratio compared to insulin glargine [82, 83], suggesting a potential renoprotective effect in individuals with type 2 diabetes

As HO-1 is produced by the transcription of Nrf2, effecting as an antioxidant enzyme (Itoh et al., 1997), we also measured the level of HO-1

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