Wellcome Open Res
Ethics declarations Ethical statement There was no need for ethics approval
(Note: recipients of 0.8mg doses had lower side effect rates when doses were slowly escalated over weeks, rather than going from nothing to 0.8mg all at once)
[28] [29] Call 999 or go to A&E immediately if you experience: Severe chest pain or symptoms of a serious allergic reaction Severe, sudden vision problems (possible acute angle-closure glaucoma with topiramate) Severe, persistent abdominal pain with or without vomiting (possible pancreatitis) Contact your GP urgently or call NHS 111 if you experience: Persistent nausea, vomiting, or abdominal pain Right upper abdominal pain, fever or jaundice (possible gallbladder disease) Signs of dehydration (dark urine, dizziness, reduced urination) Significant increases in heart rate or palpitations Mood changes, depression, or thoughts of self-harm Symptoms of hypoglycaemia (if diabetic): trembling, sweating, confusion Contact your GP or specialist if: You are considering combining weight-loss medications Current medication is not producing expected results You experience troublesome side effects from prescribed treatments You have obtained medications from unregulated sources You require support with weight management strategies Transparent communication with healthcare professionals ensures safe, effective, and personalised approaches to achieving and maintaining a healthy weight
Talk to your healthcare provider if another medication could be a better fit for you, such as: How long does it take to lose weight on semaglutide
Nohigher starting doses increase nausea and side effects without accelerating weight loss
