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Pathogenesis of Diabetic Gastroparesis There are multiple mechanisms linking diabetes to gastric motor dysfunction, such as autonomic neuropathy, enteric neuropathy involving excitatory and inhibitory nerves, abnormalities of ICC [54] (Table 3), acute fluctuations in blood glucose, incretin-based medications used to normalize postprandial blood glucose (Table 5) and perhaps psychosomatic factors via autonomic mechanisms

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TMAO is an independent risk factor of cardiovascular morbidity and mortality in patients with established IHD or CKD 18,19 with accumulating evidence suggesting direct causal effects 47

High-resolution T1-weighted structural images will be acquired for anatomical reference