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Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme catalyzing the breakdown of heme to biliverdin and iron producing carbon monoxide (CO) as a byproduct

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However, the observation that the sensitization rate to common allergens in cities in eastern Germany with previously high levels of traditional air pollutants such as SO 2 or particulate matter was low in comparison to that of western Germany cities argues against the hypothesis that traditional air pollution from industrial production and household coal burning is the major factor driving the changes in morbidity patterns of allergic disease (von Mutius et al., 1992

Key glutathione benefits for skin: Skin Lightening & Brightening: It suppresses the enzyme tyrosinase, which is responsible for melanin production, reducing dark spots and promoting a brighter, more even skin tone

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This conclusion was also reached in another study (5)