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In the STEP 1 extension study, participants who stopped semaglutide after 68 weeks regained roughly two-thirds of their lost weight within a year

One meta-analysis found that patients who used semaglutide or tirzepatide regained an average of 910 kilograms

This surveillance, encompassing regular blood and urine tests, DNA methylation tests, and medical scans, is essential to not only gauge the peptide's effectiveness but also to closely monitor any emerging safety concerns

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For example, semaglutide dosing differs substantially between Ozempic (diabetes) and Wegovy (weight management)