In January 2024, Department of Health secretary Ted Herbosa warned about the illegal administration of IV glutathione for skin lightening

Product Features Fading melasma Reduces dark patches and evens out skin tone Fading acne scars & dark spots Visibly lightens post-acne marks Preventing freckles & hyperpigmentation Helps block future discoloration Key Ingredients - Arbutin 5% - Tranexamic Acid - Glutathione How to use Apply small amount directly onto spots or areas of discoloration Ingredients Water, Arbutin, Glycerin, Cetearyl Alcohol, Butylene Glycol, Niacinamide, Caprylic/Capric Triglyceride, Glyceryl Stearate, Cetyl Ethylhexanoate, Simmondsia Chinensis (Jojoba) Seed Oil, Pyrus Malus (Apple) Fruit Extract, Cetearyl Glucoside, Oenothera Biennis (Evening Primrose) Oil, Persea Gratissima (Avocado) Oil, Plukenetia Volubilis Seed Oil, Thuka Orientalis Leaf Extract, Zanthoxylum Piperitum Fruit Extract, Polygonum Cuspidatum Root Extract, Citrus Limon (Lemon) Fruit Extract, Ginkgo Biloba Leaf Extract, Polygala Tenuifolia Root Extract, Platycodon Grandiflorus Root Extract, Centella Asiatica Extract, Hipophae Rhamnoides Fruit Extract, Coptis Japonica Extract, Pyrus Communis Fruit Extract, Iris Florentina Root Extract, Cucumis Melo (Melon) Fruit Extract, Hedera Helix (Ivy) Leaf/Stem Extract, Rosa Damascena Flower Water, Allantoin, Sodium Hyaluronate, Ascorbyl Glucoside, Tranexamic Acid, Glutathione, Arginine, Adenosine, Caprylyl Methicone, Sorbitan Oleate, Sorbitan Olivate, Sorbitan Sesquioleate, Tocopherol, C12-20 Alkyl Glucoside, Carbomer, Sodium Acryloyldimethyl Taurate Copolymer, 1,2-Hexanediol, Benzyl Glycol, Ethylhexylglycerin, Raspberry Ketone, Disodium EDTA Content 20 ml / 0.7 oz For Topical and Cosmetic Use Only

and F.S., critically reviewed the manuscript
The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione
Moreover, due to its high hydrophilicity, the absorption efficiency of plain glutathione through intestinal mucosal cells is limited
1999), demonstrating that GT plays a central role in the supply of cysteine to neurons