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Taken together it is clear that risk assessment for chemically induced allergic disease has two components: (a) the likelihood that a chemical will induce sensitization in a previously unsensitized individual

JAMA Dermatol 2016

It may also interfere with the PI3K/Akt/mTOR signaling pathways involved in HIF-1 activation and promote the degradation of HIF-1 protein through the 26S proteasome system, a cellular machinery responsible for protein breakdown 48

The risk of shingles and its complications increases with age, due to a decline in cell-mediated immunity to VZV

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