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secondary IR cross-reactivity Key downstream pathways / PI3K-Akt-mTOR and RAS-MAPK-ERK IGF-1 DES comparison / DES is 6-aa truncated, 10x higher potency but even shorter half-life (~20-30 min) Regulatory status / Not FDA-approved for any indication

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In contrast, foods rich in dietary fiber increase the diversity of the gut microbiota and the production of metabolites, including SCFAs, which have anti-inflammatory effects (160, 161)

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Opportunities and challenges in delivering biologics for Alzheimers disease by low-intensity ultrasound