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La excrecin es unidireccional, ya que el resto del GSH hidrfilo impide que se vuelva a difundir nuevamente el conjugado a travs de la membrana plasmtica, excretando estos compuestos como cidos mercaptoricos (fase III) que aparecen en la orina (fig

Gastroenterology 128, A584

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Interestingly, no substantial effects of hydrochlorothiazide or chlorthalidone on plasma insulin were reported in several of these and other trials (Klauser et al., 1991